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WELLNESS – preventive formulation Cannabinoid Clinic

38,90 

WELLNESS – preventive formulation by ICANNA, 600 mg cannabinoids, 200 mg terpenes

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SKU: 0002-4-1-1-1-1 Category:

Description

 

Benefits of cannabinoids in improving life quality

Endocannabinoid system (ECS) is present in almost all body tissues and cells. Its good functioning is a prerequisite for the homeostasis (balance) of all metabolic processes in the body. Modern lifestyle depletes ECS with toxins inhaled, ingested through food or water, stress, viruses and anything else that destroys the body’s balance. Therefore, ECS is being depleted due to too frequent switching on in order to maintain body’s balance. Science confirms that ECS must be renewed and maintained. Probably most people after the age of 40 should take cannabinoids to maintain long-term health.

  1. Cannabidiol or CBD

Studies have showed that CBD is systemically efficient as an anti-inflammatory molecule. It decreases inflammation in all body tissues and modulates immune response, so there are fewer inflammatory cytokines in the body. Even by applying it topically on inflamed joints, it exhibits anti-inflammatory action. Gel form of CBD was well absorbed and decreased inflammation, swelling, hypersensitivity of joints, and pain. Oral CBD application very efficiently stops arthritis progression and protects joints from further damage. They have also established that CBD was particularly effective when used in the early stages of arthrosis (wear and tear of joints), as it prevented the nerve damage and pain commonly associated with the disease. Animal experiments have also confirmed that CBD has an important preventive role in arthrosis. When rats were given CBD in the laboratory as a preventive measure and then they caused them arthrosis, there was little or no inflammation or pain.

  1. Cannabidiolic acid or CBDA

CBDA has a wide range of effects that are important in joint health and flexibility, as well as in immune response. It is proven to reduce swelling and it has a strong anti-inflammatory effect. CBDA is important in chronic inflammations that are usually accompanied by chronic pain and hyperalgesia, or hypersensitivity to pain stimuli. CBDA has not been studied so well from the perspective of all effects and mechanisms. However, clinical practice and patients’ experience have shown that CBDA is of a key importance when it comes to states related to inflammatory processes and improper immune response (allergies, autoimmune diseases, or weak immune response).

3. Curcumin

Turmeric contains the active ingredient curcumin, which is from traditional Eastern medicine known as a powerful anti-inflammatory substance. A study was carried out on volunteers with the knee osteoarthritis, and after one month of taking curcumin 94% of the participants reported more than 50% improvement in their knee. Turmeric has been used in nutrition and is considered very safe. It is categorized as GRAS (Generally Recognized as Safe). Curcumin efficiency has been established in osteoarthritis, type 2 diabetes, dyslipidaemia because its anti-inflammatory and antioxidant action regulates the immune response and limits inflammatory processes.

4. Black pepper essential oil

Black pepper essential oil contains an active ingredient called piperine. This substance has several well studied effects on a body. In various research models of inflammatory diseases, it has been established to reduce pain and swelling, and to improve blood circulation. In animal models of arthritis, it has clearly proven to be a potent anti-inflammatory, analgesic, and anti-arthritic molecule. Moreover, piperine is a known bioenhancer – a substance that improves the bioavailability/absorption of a wide range of molecules, including CBD and curcumin.

After the original text of dr. Tanja Bagar, assist. prof.

Additional information

Opcije

10ml, 30ml

science on immune system

Pomen kanabinoidov in terpenov za imunski sistem

Imunski sistem si lahko predstavljamo kot mrežo številnih organov, tkiv in celic. Začne se v kostnem mozgu, prožnem tkivu znotraj kosti, kjer nastajajo matične hematopoetske celice. Iz teh nezrelih matičnih celic zorijo vse imunske celice. Poleg kostnega mozga je primarni imunski organ še timus (priželjc), kjer zorijo limfociti T. Sekundarni imunski organi pa so vranica, limfni sistem in bezgavke, žrelnica, nebnici, koža in jetra. Tu se imunske celice srečujejo s patogeni in se borijo proti njim. V imunski odziv je vključeno celotno telo. Poleg organov imunskega sistema ima telo veliko celic s specifičnimi imunskimi vlogami.

Vsi se rodimo s prirojeno imunostjo, ki nudi splošno in nespecifično zaščito. Vključuje kožo in sluznice, ki so prva obrambna linija pri preprečevanju vstopa patogenov v telo. Prednost prirojenega imunskega odgovora je v tem, da se odzove zelo hitro in v polnem razmahu, ne glede na to, ali se z določenim mikrobom srečamo prvič, ali smo se že mnogokrat. Prirojeni imunski odgovor vključuje vnetni odziv, proizvodnjo citokinov, aktivacijo določenih imunskih celic kot so fagociti, bazofilci, mastociti in eozinofilci.

Poleg prirojenega poznamo še specifični imunski odgovor (denimo tvorba protiteles), ki traja od nekaj dni do celo nekaj tednov (odvisno od patogena). Ta imunost se razvija skozi vse življenje. Temelji na limfocitih in se razvije, ko smo izpostavljeni mikrobom ali pa cepljeni. Poznamo pasivno in aktivno imunost. Pasivna imunost pomeni, da si jo na nek način »izposodimo« od drugod, in deluje le kratek čas. Na primer, protitelesa v materinem mleku nudijo dojenčku začasno imunost na bolezni, ki jih je mati že prebolela, kar pomaga zaščititi otroka pred okužbo v zgodnjih letih otroštva. Aktivna imunost pa se razvije, kadar smo sami neposredno izpostavljeni patogenom ali njihovim antigenom. To je dolgoročna imunost in se pridobi z aktivacijo limfocitov B in T, sodelujejo pa tudi citokini. Med pridobljenim imunskim odgovorom se oblikujejo posebne spominske celice, ki si zapomnijo specifični patogen, in če smo mu ponovno izpostavljeni, imunski sistem reagira veliko hitreje.

Vsak imunski sistem je drugačen. Zdi se, da nekateri ljudje nikoli ne zbolevajo, drugi pa so bolni kar naprej. Načeloma imajo odrasli ljudje bolj razvit in uspešnejši imunski sistem, ker so v življenju prišli v stik z več mikrobi. A to ni pravilo, saj na imunski odziv vpliva veliko dejavnikov in za učinkovit imunski odgovor se morajo odviti številni procesi ob pravem času in na pravem mestu.

Vse več raziskav kaže, da je vnetje del večine kroničnih bolezni, tudi malignih. Porušen oz. neustrezen imunski odgovor je del patološkega procesa mnogih vnetnih in avtoimunih bolezni. Revmatoidni artritis je kronična vnetna avtoimuna sistemska bolezen. Je najpogostejša izmed revmatskih vnetnih bolezni. Lahko se pojavi v vsaki starosti, pogosteje zbolevajo ženske. Prevalenca bolezni je 1% in se veča s starostjo, po 55. letu se približuje 2-5%.

Avtorica teksta: doc. dr. Tanja Bagar

Na splošno je oralna absorpcija kanabinoidov zelo nizka. Le približno 3-10% zaužitih kanabinoidov doseže kri. Na absorpcijo CBD pomembno vplivata dva dejavnika: različna presnova pri vsakem posamezniku in absorpcijski potencial CBD-olja (najvišjega ima CBD olje polnega spektra z zadostno količino CBDa, najnižjega pa izolirani CBD).

Vsak posameznik mora sam najti ustrezen peroralni odmerek kanabinoidne formulacije. Priporočamo, da začnete s samo 2-3 mg (1-2 kapljicami) in povečujete dnevni odmerek za kapljico ali dve. Bolniki s hudimi težavami potrebujejo odmerke do 100 mg dnevno. Običajni dnevni odmerek je med 15-30 mg. Kanabinoidno formulacijo nakapate pod jezik in ga tam zadržite minuto, lahko tudi dlje. Del CBD-ja se bo absorbiral skozi kapilare pod jezikom in njegov učinek se zazna že po približno 15 minutah. Nato CBD kapljice pogoltnete. Po zaužitju traja približno eno uro in pol, da doseže CBD svojo najvišjo raven v krvi. Učinek CBD-ja počasi izzveni v 4-8 urah po zaužitju.

Absorpcijo kanabinoidov lahko občutno izboljšamo, če jih zaužijemo po obroku, zlasti takšnem, ki je bogat z maščobami.

Pomembno: kanabinoidi inhibirajo (upočasnijo) delovanje jetrne encimske skupine CYP450, ki presnavlja številna zdravila. Na splošno to povzroči višjo raven teh zdravil v krvi. To morate upoštevati in se pogovoriti s svojim zdravnikom, da bo prilagodil (verjetno znižal) odmerek zdravila. Pri količinah do 30 mg kanabinoidov (cca 15 kapljic) do resnejše interakcije z večino zdravil še ne prihaja.

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