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Benefits of cannabinoids and terpenes in managing pain<\/em><\/strong><\/p>\n Several clinical trials have been conducted and published in which participants used either synthetic or plant-based cannabinoids, as well as smoking cannabis for relieving pain. Trials conducted using synthetic cannabinoids gave different results. The trials have mainly used dronabinol and cesamet (nabilone), both synthetic analogues of THC, meaning they are very similar to it and bind to the same receptors. Patients are selected very carefully for clinical trials, usually with very specific pain symptoms, so it is often difficult to draw general conclusions from such studies that would help a typical patient with pain.<\/p>\n Most of the trials have confirmed a pain relief. In the case of rheumatoid arthritis, mobility improved and morning stiffness was alleviated, and in most patients sleep has been improved as well.<\/p>\n Many researches on pain focused on effect of THC or its analogues. However, lately an increasing number of patients\u2019 experience and researches show the importance of CBD and other plant-based cannabinoids and terpenes in case of chronic pain. From the perspective of the inflammatory theory of pain, as well as central and peripheral sensitisation in chronic pain, the use of plant-based cannabinoids is rational.<\/p>\n Formulation\u2019s key ingredients are the following:<\/p>\n CBD is known to have a high anti-inflammatory effect and to regulate activity of neurons. It also modulates endocannabinoid system, especially anandamide concentrations as it decreases its degradation and thus causing its higher concentration. It also binds to TRPV, serotonin and other receptors. CBD cannot be expected to provide immediate pain relief, but when used over a long period of time, it can provide central and peripheral desensitisation, pain relief, improved sleep and general well-being.<\/p>\n CBDA has several effects that are important in addressing pain, reducing swelling, and has its own mechanism of pain relief action, which occurs at lower doses than CBD. CBDA is particularly important in pain that has an inflammatory component and in chronic pain where hyperalgesia or hypersensitivity to pain stimuli is present.<\/p>\n Cannabigerol (CBG) has significant analgesic and anti-erythraemic effects (alleviation of morbid redness of the skin), inhibits AEA uptake and binds to TRPV1-receptors. CBG also modulates certain enzymes in the biochemical cascade of pain, contributing to the analgesic action of the formulation.<\/p>\n Limonene is a terpene found in various plants and is well studied. It has a wide range of effects, including effect on pain. It has proved particularly useful for chronic muscular-skeletal pain and for hypersensitivity to pain stimuli. In Slovenia, many patients suffer from muscular-skeletal pain, especially in fibromyalgia and multiple sclerosis, which is why we have included limonene in the formulation.<\/p>\n Rosemary essential oil contains a number of active ingredients, including but not limited to terpenes such as camphene, pinene, limonene, myrcene, as well as other active ingredients such as carnosic acid, carnosol, and rosmarinic acid. Traditionally, rosemary extracts have been used for various problems, such as spasms, pain, headaches, and migraines. Today, science confirms the effectiveness of rosemary’s active ingredients in treating pain, especially pain associated with muscle spasms and tension, such as migraines and tension headaches.<\/p>\n Lemon grass essential oil contains terpenes, alcohols, ketones, aldehydes, and esters. In terms of addressing pain, the most important terpene is myrcene, obtained from lemon grass essential oil. Its analgesic activity has been demonstrated in several different research models and dose-dependent analgesia has been demonstrated.<\/p>\n In adjacent tabs, read the texts written by dr. Tanja Bagar about what science today says about the pain<\/strong> and how cannabinoids supplement the established pain relief therapies<\/strong>.<\/p>\n","protected":false},"excerpt":{"rendered":" PAIN CONTROL – pain management cannabinoid formula, 600 mg cannabinoids, 200 mg terpenes<\/p>\n","protected":false},"featured_media":1690,"template":"","meta":{"_mi_skip_tracking":false},"product_cat":[7],"product_tag":[],"acf":[],"yoast_head":"\n\n
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