GOOD NIGHT – sleep formulation Cannabinoid Clinic


GOOD NIGHT – cannabinoid-terpene formulation for better sleep, 600 mg cannabinoids, 200 mg terpenes

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Benefits of cannabinoids and terpenes for poor sleep patterns

The relationbetween sleep and cannabis is well studied. Evidence shows that hemp has been used in Ayurvedic medicine for thousands of years to improve sleep, and today science confirms the rationality of this approach. Endocannabinoid system is increasingly important target for establishing a healthy day/night rhythm. The main biological clock in our body is located in a region of the brain called the suprachiasmatic nuclei. This is a very small region of the brain located within the hypothalamus which is located directly above the optic chiasm. Based on the light detected by intrinsically photosensitive cells (ipRGCs), it receives information on the time of the day. This is how our internal clock synchronises and adjusts to the planet’s day/night cycle.

Plant-based cannabinoids such as THC, CBD, CBG and others affect sleeping, but several factors such as cannabinoid ratios, dosages, time of administration, and route of administration are important as they influence the effect on sleep. THC is known as a cannabinoid that activates sleeping or a feeling of sleepiness and relaxation, and can help those who find it difficult to fall asleep at night. However, research shows that it does not affect the quality of sleep, and often this drowsiness effect declines over time, forcing users to increase their doses.

  1. Cannabidiol or CBD

CBD’s effect on sleep is very individual, rare individuals (5%) experience an effect similar to caffeine, and they feel awake and full of energy, but in some people (5%) it triggers relaxation and slight sleepiness. Most people do not sense acute effects, but there is no doubt that CBD regulates the day/night rhythm in all people, and it helps to establish or maintain an internal balance which also helps to achieve a better night’s sleep.

  1. Cannabidiolic acid or CBDA

CBDA is important as it improves CBD’s oral absorption, but it also has a positive effect on a day/night rhythm balance and production of the relevant neurotransmitters. CBDA also modulates serotonin receptors helping to calm down and prepare for sleep. Especially in periods of high stress, CBDA decreases tension, anxiety, and potential nausea that can occur, therefore helping a body to slip into a healthy sleep.

  1. Lavender essential oil

Lavender has traditionally been used for relaxation, has a mild anxiolytic (anti-anxiety) effect, stabilises mood and is a mild sedative. Science now confirms that the lavender’s active ingredients have a range of beneficial effects on nervous system. The most important active ingredients of lavender essential oil are the terpenes linalool, linalyl acetates, cineoleocimene, and camphor. Among them, linalool is the best studied from the perspective of its effect on circadian rhythm and sleep. However, it is important to use lavender essential oil, which contains the full spectrum of active ingredients, not just one isolated terpene, as the effects are synergistic. Studies have shown that both inhalation and oral administration improve quality of sleep, with faster slip to sleep and longer sleep duration. Studies have also shown that the active compounds in lavender have similar positive effects on the body as melatonin, which is produced by the pineal gland during healthy sleep.

  1. Lemon grass essential oil

Lemon grass essential oil contains terpenes, alcohols, ketones, aldehydes, and esters. The use of lemon grass essential oil prolongs sleep time, so this ingredient in the formulation is particularly important for people who wake up a lot. Mircen is the most important terpene contained in the lemon grass essential oil. It has been shown to relax the locomotor apparatus, further helping to prepare the body for sleep and rest.

  1. Frankincense (Boswellia) essential oil

Frankincense essential oil contains sesquiterpenes, which cross the blood brain barrier and increase oxygen levels in the brain regions around the pineal gland and pituitary gland, both very important glands for circadian rhythms and sleep. The pituitary gland is the centre of the body’s master biological clock, which regulates all our body systems, while the pineal gland produces melatonin, which is secreted only at night during sleep and is crucial for long-term health.

Author: dr. Tanja Bagar, assist. prof.


Read more in the adjacent tab Science on Sleep.

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10ml, 30ml

science on sleep

The importance of cannabinoids and terpenes for a better night’s sleep

Sleeping problems are a global problem influencing health and quality of life of almost 45% of the worldwide population. The most common sleep disorder reported by patients in the family doctor’s practice is insomnia. Up to 20% suffer from chronic insomnia, while up to 45% of adult population experience acute form of insomnia at least once in a life time. Insomnia’s frequency is increased after 65 years of age. Women more often suffer from insomnia than men.

Insomnia should not be seen as just a problem with falling asleep or staying asleep, but as part of the circadian rhythm, the 24-hour day/night cycle. Sleep problems are primarily a sign that the circadian rhythm is in imbalance, and to improve your sleep in the long term, it is essential to restore the balance of your internal clock or circadian rhythm.

The endocannabinoid system (ECS) is the overarching signalling system that maintains the biochemical balance of our body, as a kind of protective mechanism that protects the functioning of our body, starting at the cellular level, through tissues and organs, to the functioning of the whole body and our emotions. Researches of the ECS have discoveredthat its elements are present in the majority of body systems and types of cells. It has been established that the ECS affects functioning of the majority of cells, tissues, and organs. Finding an explanation of what exactly the ECS does in our body has been a challenge, as the results suggest that it affects all key processes in our cells, including circadian rhythms and sleep. Studies have revealed that the ECS is a kind of link between the circadian system – our internal clock – and the physiological processes that change over a 24-hour cycle. It has been proven beyond doubt that insomnia, or lack of quality sleep, causes ECS dysfunction and that improving the endocannabinoid system functioning (increasing ECS tone) quickly leads to improved sleep quality. It is very obvious that the ECS and circadian rhythm are closely related and intertwined, and that imbalance of one strongly affects the other one.

The endocannabinoid system is critically involved in regulating the overall circadian rhythm, especially the slipping into sleep and maintenance thereof, which is why the ECS is a very important target if we want to address sleep problems comprehensively.

The majority of the physical processes in our body is regulated by circadian rhythm, and an increasing amount of data reveals that circadian rhythm disorders or a discrepancy in circadian rhythmicity contributes significantly to the onset of the disease. Studies reveal that the ECS is a key link between our internal clock and physiological responses. Plant-based cannabinoids (and, to some extent, synthetic analogues) show enormous potential for regulating circadian rhythm imbalances and sleep. Through their primary function of creating biochemical balance, cannabinoids modulate the activity of suprachiasmatic nucleus and the central circadian clock, as well as other physiological processes (such as the production of neurotransmitters and hormones), which contributes to overall health and well-being, as well as to healthy sleep.

Insomnia and other sleep disorders are becoming largely wide-spread in a modern society. If they become a chronic issue, this is related to increased healthcare risks. Thus, a proper and comprehensive support for a healthy sleep is so important. Researches show that cannabinoids, used at the right time and in the right concentration and composition, can be very beneficial for slipping into sleep and proper sleep pattern. It is probably because of their modulating effects on the circadian clock that they make an important contribution to individual and societal health and well-being and productivity.

Author: dr Tanja Bagar, assist. prof.

Generally, oral absorption of cannabinoids is very low. Only about 3–10% of the ingested cannabinoids come into bloodstream. Absorption of CBD is importantly influenced by two factors: different metabolism of each individual and absorption potential of the CBD oil (full-spectrum CBD oil with sufficient CBD has the highest absorption potential, isolated CBD has the lowest).

It is up to each individual to find the appropriate oral dosage of a cannabinoid formulation. We recommend you start with only 2–3mg (1–2 drops) and increase the daily dosage for a drop or two. Patients with severe problems need dosages up to 100mg per day. The usual daily dosage is between 15 and 30mg. Apply cannabinoid formulation under a tongue and keep it there for a minute or longer. A part of the CBD will be absorbed through the capillaries under the tongue. Its effect is felt after approximately 15 minutes. Then swallow the CBD drops. After ingestion, it takes about one and a half hour for CBD to reach its peak level in blood. CBD’s effect slowly clears up within 4-8 hours after ingestion.

Cannabinoid’s absorption can be significantly improved by applying them after a meal, especially a meal rich in fat.

Important: Cannabinoids inhibit (slow down) functioning of the CYP450 enzyme, which metabolises many medicines. Generally, this causes a higher level of these medicines in blood. You should take this into account and talk to your doctor to adjust (probably lower) the dose of the medicine. At levels of up to 30mg of cannabinoids (approx. 15 drops), no serious interactions with most medicines have yet occurred.